Marc A Vos Selected Research

Atrioventricular Block

1/2022	The canine chronic atrioventricular block model in cardiovascular preclinical drug research.
1/2021	Interplay between temporal and spatial dispersion of repolarization in the initiation and perpetuation of torsades de pointes in the chronic atrioventricular block dog.
12/2020	High-rate pacing guided by short-term variability of repolarization prevents imminent ventricular arrhythmias automatically by an implantable cardioverter-defibrillator in the chronic atrioventricular block dog model.
10/2019	LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
1/2018	Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
1/2018	Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs.
1/2018	Beat-to-beat variations in activation-recovery interval derived from the right ventricular electrogram can monitor arrhythmic risk under anesthetic and awake conditions in the canine chronic atrioventricular block model.
1/2018	An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog.
12/2017	Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry.
6/2017	Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog.

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Marc A Vos Research Topics

Disease

31	Atrioventricular Block 01/2022 - 08/2003
30	Torsades de Pointes (Torsade de Pointes) 01/2021 - 08/2003
18	Cardiac Arrhythmias (Arrythmia) 01/2022 - 11/2002
16	Heart Failure 11/2021 - 03/2002
13	Fibrosis (Cirrhosis) 01/2021 - 09/2010
10	Hypertrophy 10/2021 - 08/2003
7	Cardiomegaly (Heart Hypertrophy) 10/2021 - 03/2002
7	Atrial Remodeling 01/2018 - 08/2003
6	Heart Diseases (Heart Disease) 04/2014 - 09/2008
5	Long QT Syndrome 06/2017 - 12/2002
4	Shock 01/2020 - 03/2012
4	Ventricular Remodeling 01/2017 - 08/2008
4	Ventricular Tachycardia 01/2016 - 07/2010
3	Cardiomyopathies (Cardiomyopathy) 12/2021 - 03/2013
3	Cardiac Sudden Death (Sudden Cardiac Arrest) 03/2017 - 11/2003
3	Atrial Fibrillation 12/2011 - 11/2006
2	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2021 - 03/2012
2	Cardiotoxicity 12/2019 - 10/2009
2	Systolic Heart Failure 01/2018 - 01/2017
2	Polymorphic catecholergic ventricular tachycardia 04/2014 - 07/2010
2	Bradycardia 03/2012 - 02/2007
2	Myocardial Infarction 12/2011 - 10/2010
1	Inflammation (Inflammations) 10/2021
1	Cicatrix (Scar) 10/2020
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2019
1	Neoplasms (Cancer) 01/2019
1	Bundle-Branch Block (Fascicular Block) 12/2018
1	Long QT syndrome type 3 01/2018
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 12/2017
1	Hypoxia (Hypoxemia) 11/2017
1	Infarction (Infarctions) 01/2017

Drug/Important Bio-Agent (IBA)

31	Pharmaceutical PreparationsIBA 01/2022 - 11/2002
17	dofetilide (Tikosyn)FDA Link 01/2021 - 08/2003
9	Connexin 43 (Connexin43)IBA 01/2016 - 03/2007
8	Proteins (Proteins, Gene)FDA Link 12/2021 - 09/2008
7	CalciumIBA 01/2020 - 12/2011
5	CollagenIBA 01/2014 - 05/2011
4	Messenger RNA (mRNA)IBA 10/2021 - 01/2005
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2010
4	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2020 - 11/2012
4	Anti-Arrhythmia AgentsIBA 01/2018 - 07/2010
4	salicylhydroxamic acid (SHAM)IBA 01/2016 - 07/2011
3	SodiumIBA 01/2018 - 01/2012
3	Ion Channels (Ion Channel)IBA 10/2017 - 12/2002
3	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 04/2014 - 07/2010
3	CalcineurinIBA 01/2014 - 09/2008
2	phospholambanIBA 12/2021 - 11/2012
2	Anesthetics (Anesthetic Agents)IBA 01/2018 - 01/2015
2	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 01/2017 - 10/2004
2	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2016 - 11/2012
2	RNA (Ribonucleic Acid)IBA 01/2014 - 09/2008
2	Sodium Channels (Sodium Channel)IBA 03/2013 - 04/2012
2	Adrenergic Agents (Adrenergic Drugs)IBA 02/2012 - 10/2006
2	Protein Isoforms (Isoforms)IBA 09/2008 - 01/2003
2	sertindole (Serdolect)IBA 09/2006 - 11/2003
1	InterleukinsIBA 10/2021
1	Brain Natriuretic Peptide (Natrecor)FDA Link 10/2021
1	Toll-Like Receptor 4IBA 10/2021
1	procollagen type I carboxy terminal peptide (PICP)IBA 01/2021
1	Indicators and Reagents (Reagents)IBA 10/2020
1	Peptides (Polypeptides)IBA 01/2020
1	Eplerenone (Inspra)FDA LinkGeneric 01/2020
1	autocamtide 3IBA 01/2020
1	3-(2-carboxyindol-3-yl)propionic acidIBA 12/2019
1	LUF7244IBA 10/2019
1	Cadherins (E-Cadherin)IBA 01/2019
1	flotillinsIBA 01/2019
1	6- (4- (trifluoromethoxy)phenyl)- 3- (trifluoromethyl)(1,2,4)triazolo(4,3- a)pyridineIBA 01/2018
1	ElectrolytesIBA 01/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2018
1	Hormones (Hormone)IBA 01/2018
1	IstaroximeIBA 01/2018
1	AntigensIBA 12/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2017
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2017
1	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 12/2015
1	C.I. direct red 80IBA 11/2015
1	Connective Tissue Growth FactorIBA 11/2015
1	Methoxamine (Methoxamine Hydrochloride)FDA Link 01/2015
1	MicroRNAs (MicroRNA)IBA 01/2014
1	alpha2 Subunit Collagen Type IIBA 01/2014
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2014
1	tert-butyl (2- (7- (2- (4- cyano- 2- fluorophenoxy)ethyl)- 9- oxa- 3,7- diazabicyclo(3.3.1)non3- yl)ethyl)carbamateIBA 11/2013
1	vernakalantIBA 11/2013
1	SEA 0400IBA 04/2013
1	gamma Catenin (Plakoglobin)IBA 03/2013
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 11/2012
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/2012
1	Ether (Diethyl Ether)IBA 10/2012
1	Verapamil (Calan)FDA LinkGeneric 05/2012
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 05/2012
1	Calcium Channels (Calcium Channel)IBA 05/2012
1	Contrast MediaIBA 12/2011

Therapy/Procedure

9	Therapeutics 11/2021 - 03/2002
4	Cardiac Resynchronization Therapy 11/2021 - 01/2018
4	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 12/2020 - 03/2012
2	Electrodes (Electrode) 12/2017 - 07/2004
2	Defibrillators (Defibrillator) 03/2017 - 07/2010
1	Heart Transplantation (Grafting, Heart) 01/2020